Plant Transcription Factor Database
Previous version: v3.0
Capsella rubella
M-type_MADS Family
Species TF ID Description
Carubv10001114mM-type_MADS family protein
Carubv10001166mM-type_MADS family protein
Carubv10001421mM-type_MADS family protein
Carubv10001714mM-type_MADS family protein
Carubv10001920mM-type_MADS family protein
Carubv10002555mM-type_MADS family protein
Carubv10002683mM-type_MADS family protein
Carubv10002712mM-type_MADS family protein
Carubv10002761mM-type_MADS family protein
Carubv10002787mM-type_MADS family protein
Carubv10002823mM-type_MADS family protein
Carubv10003161mM-type_MADS family protein
Carubv10003642mM-type_MADS family protein
Carubv10003716mM-type_MADS family protein
Carubv10003757mM-type_MADS family protein
Carubv10006189mM-type_MADS family protein
Carubv10006209mM-type_MADS family protein
Carubv10006654mM-type_MADS family protein
Carubv10006793mM-type_MADS family protein
Carubv10007456mM-type_MADS family protein
Carubv10007591mM-type_MADS family protein
Carubv10007644mM-type_MADS family protein
Carubv10008056mM-type_MADS family protein
Carubv10009419mM-type_MADS family protein
Carubv10010156mM-type_MADS family protein
Carubv10010430mM-type_MADS family protein
Carubv10010438mM-type_MADS family protein
Carubv10010833mM-type_MADS family protein
Carubv10011075mM-type_MADS family protein
Carubv10011216mM-type_MADS family protein
Carubv10011303mM-type_MADS family protein
Carubv10011345mM-type_MADS family protein
Carubv10011458mM-type_MADS family protein
Carubv10011611mM-type_MADS family protein
Carubv10012009mM-type_MADS family protein
Carubv10012214mM-type_MADS family protein
Carubv10012265mM-type_MADS family protein
Carubv10012479mM-type_MADS family protein
Carubv10012603mM-type_MADS family protein
Carubv10014232mM-type_MADS family protein
Carubv10014761mM-type_MADS family protein
Carubv10015167mM-type_MADS family protein
Carubv10015354mM-type_MADS family protein
Carubv10015981mM-type_MADS family protein
Carubv10015986mM-type_MADS family protein
Carubv10016398mM-type_MADS family protein
Carubv10017440mM-type_MADS family protein
Carubv10017446mM-type_MADS family protein
Carubv10019521mM-type_MADS family protein
Carubv10021360mM-type_MADS family protein
Carubv10021362mM-type_MADS family protein
Carubv10021425mM-type_MADS family protein
Carubv10021446mM-type_MADS family protein
Carubv10021540mM-type_MADS family protein
Carubv10021715mM-type_MADS family protein
Carubv10021725mM-type_MADS family protein
Carubv10021738mM-type_MADS family protein
Carubv10021761mM-type_MADS family protein
Carubv10021762mM-type_MADS family protein
Carubv10021825mM-type_MADS family protein
Carubv10021838mM-type_MADS family protein
Carubv10021917mM-type_MADS family protein
Carubv10022052mM-type_MADS family protein
Carubv10022123mM-type_MADS family protein
Carubv10022197mM-type_MADS family protein
Carubv10022233mM-type_MADS family protein
Carubv10022252mM-type_MADS family protein
Carubv10022431mM-type_MADS family protein
Carubv10024482mM-type_MADS family protein
Carubv10024493mM-type_MADS family protein
Carubv10024608mM-type_MADS family protein
Carubv10024652mM-type_MADS family protein
Carubv10024749mM-type_MADS family protein
Carubv10024813mM-type_MADS family protein
Carubv10024914mM-type_MADS family protein
Carubv10024968mM-type_MADS family protein
Carubv10025009mM-type_MADS family protein
Carubv10025317mM-type_MADS family protein
Carubv10025411mM-type_MADS family protein
Carubv10025621mM-type_MADS family protein
Carubv10025656mM-type_MADS family protein
Carubv10025699mM-type_MADS family protein
Carubv10027564mM-type_MADS family protein
Carubv10027979mM-type_MADS family protein
Carubv10028105mM-type_MADS family protein
Carubv10028378mM-type_MADS family protein
Carubv10028580mM-type_MADS family protein
M-type_MADS (M-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513